Journal article
The impact of schizophrenia and intelligence on the relationship between age and brain volume
MH Jensen, N Bak, E Rostrup, M Nielsen, C Pantelis, BY Glenthøj, BH Ebdrup, B Fagerlund
Schizophrenia Research Cognition | ELSEVIER | Published : 2019
Abstract
Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline in schizophrenia compared to healthy controls. In schizophrenia, the relation between age and brain volume is further complicated by factors such as lower intelligence, antipsychotic medication, and cannabis use, all of which have been shown to have independent effects on brain volume. In a study of first-episode, antipsychotic-naïve schizophrenia patients (N = 54) and healthy controls (N = 56), we examined the effects of age on whole brain measures of GM and WM volume, and whether these relationships were moderated by schizophrenia and intelligence (IQ). Secondari..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the Lundbeck Foundation (R13-A1349, R25-A2701), Marie and Kroghs Fund (726290), Gerhard Linds Scholarship (726261), the Mental Health Services - Capital Region of Denmark and Faculty of Health and Medical Sciences, University of Copenhagen (211-0704/10-3012). Professor C. Pantelis was supported by fellowship from the Australian National Health and Medical Research Council (NHMRC, ID: 1105825) and by a grant from the Lundbeck Foundation (ID: R246-2016-3237). The funding sources had no role in study design, data collection, analysis or interpretation or the writing of the article.